TRONNAL
BIOMEDICINE
创 元 生 物
Type II [5+2]环加成反应
一步直接合成7元桥环体系。
底物实用性高，生成高张力桥头双键，多个手性中心（季碳中心）
★ 团队近年已完成30多例复杂活性天然产物的首次全合成:
J. Am. Chem. Soc. 2019, revised; J. Am. Chem. Soc. 2019, 141, 2872;
J. Am. Chem. Soc. 2018, 140, 5365; Nat. Commun. 2018, 9, 4040; Nat. Commun. 2016, 7, 10614;
Angew. Chem., Int. Ed. 2018, 57, 11365; Chem. Sci. 2018, 9,1488; Chem. Sci. 2017, 8, 4961;
Angew. Chem. Int. Ed. 2015, 54, 1754 ; J. Am. Chem. Soc. 2014, 136, 13610;
Angew. Chem. Int. Ed. 2014, 53, 11051; Angew. Chem. Int. Ed. 2013, 52, 620;
Angew. Chem. Int. Ed. 2012, 51, 12072; J. Am. Chem. Soc. 2011, 133, 14944;
J. Am. Chem. Soc. 2010, 132, 16745; J. Am. Chem. Soc. 2010, 132, 13608.
TMP
(7元桥环骨架)
Type II [5+2] 环加成反应
100 C,3h
98%
(gram sacle)
Type II
[5+2]
0
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